A Difluoroalkylation Reagent for Organocatalytic Vinylogous Nitroaldol

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November 4, 2020 0 Comments

A spot check for willpower of residual TBA ranges in  F-radiotracers for human use utilizing Dragendorff reagent

 

When using [18F]tetrabutylammonium fluoride ([18F]TBAF) within the synthesis of 18F-labeled radiotracers for scientific positron emission tomography (PET) imaging, it’s essential to substantiate that residual TBA ranges in formulated doses don’t exceed established specs (≤2.6 mg per affected person dose).

Historically this has been completed utilizing HPLC, however that is time consuming for short-lived PET radiotracers and restricted by the necessity for costly gear. This motivated us to introduce a TLC spot check for figuring out residual TBA, and we’ve got developed a brand new methodology which employs the Dragendorff reagent. Herein we report particulars of the TLC methodology and use it to quantify residual TBA in several formulations of 6-[18F]fluoro-DOPA. read more